Antibody–drug conjugates as novel anti-cancer chemotherapeutics
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چکیده
منابع مشابه
Antibody–drug conjugates as novel anti-cancer chemotherapeutics
Over the past couple of decades, antibody-drug conjugates (ADCs) have revolutionized the field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues upon dose escalation, ADCs utilize monoclonal antibodies (mAbs) to specifically bind tumour-associated target antigens and deliver a highly potent cytotoxic agent. The synergistic combination of mAbs conjugated to small...
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Conventional chemotherapeutic drugs to treat cancer suffers from the lack of selectivity towards the tumor site and thus causing damage to even healthy tissues. Drug dose escalation to therapeutically active levels is often impossible with chemotherapeutic drugs due to this toxicity. The selectivity of the treatment was improved with the introduction of monoclonal antibody drugs that are direct...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2015
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20150089